In the year 1535, Pizarro built the city which he named Ciudad de los Reys, or of the kings, on the river of Lima, in lat. 20° S; to which he removed the inhabitants of Xauxa, as a more convenient situation for the residence; of the government, and in a better country161. He built also the city of St Jago in Porto Viejo, and many other towns, both along the coast and in the inland country; and he procured from Spain horses, asses, mules, cattle, hogs, goats, and sheep, to stock his territories, and many kinds of trees and plants, such as rosemary, oranges, lemons, citrons, vines, and other fruits, wheat, barley, and other grains, with radishes, and many other kinds of vegetables, which were disseminated all over the country162. in the same year, Diego de Almagro went from the city of Cusco to the provinces of Arequipa and Chili, in lat. 30° S. The march was of great length, and he discovered a great extent of country; but he suffered great extremities of cold, hunger, and fatigue, in consequence of the ruggedness of the mountains, and the ice and snow, insomuch that many of his men and horses were frozen to death. About this time Ferdinando Pizarro came from Spain to the city of Lima, bringing with him the patent of Marquis of Atanillos, for his brother, Francis Pizarro, and a commission for Diego de Almagro, by which he was appointed governor of all the land he had hitherto discovered, and 100 leagues beyond, under the name of the New kingdom of Toledo. Ferdinando Pizarro went to the city of Cusco, of which he was made governor, and John de Rada went into Chili to Almagro, carrying with him the orders of the emperor. On receiving the letters patent of the emperor, Almagro marched directly for Cusco, which he considered to be included in his government, by which a civil war was kindled between him and Pizarro. On this march he and his people were severely oppressed by famine, and were even forced to feed upon their horses which had died four months and a half before, when on their march southwards into Chili163.

In this same year, 1535, Nunnez d'Acunha, who was governor of India for the crown of Portugal, while building a fortress, in the city of Diu, sent a fleet, under the command of Vasquez Perez del San Paio, to the river Indus, which is under the tropic of Cancer, 90 or 100 leagues to the north– west from Diu. He also sent an army against Badu, the king of Cambaia, or Guzerat, of which a renegado named Cosesofar was captain164. The fleet came to the bar of the great river Indus in December, where the same phenomena were observed as were formerly experienced by Alexander, according to the relation of Quintus Curtius165.

In the same year, Simon de Alcazava sailed from Seville, with two ships and 240 men. Some say he was destined for New Spain, others for the Moluccas, and others again that he meant to have proceeded for China, where he had formerly been, along with Ferdinando Perez de Andrada. However this may have been, he went first to the Canaries, and from thence to the straits of Magellan, without touching at Brazil, or any other part of the coast of South America, and entered into these straits in the month of December, having contrary winds, and very cold weather. Under these difficulties, the soldiers entreated him to turn back, which he refused, and went into a haven on the south side of the straits, in lat. 53° S. where he ordered Roderigo de Isla to land, with 60 of the people, to explore the country; but the people mutinied against Alcazava, and slew him; and, having appointed such captains and officers as they thought proper, they returned back. In their voyage homewards, one of the ships was lost on the coast of Brazil, and such of the Spaniards as escaped drowning, were killed and eaten by the savages. The other ship went to St Jago, in the island of Hispaniola, and thence returned to Seville, in Spain166. In the same year, Don Pedro de Mendoзa went from Cadiz for the river Plata, with twelve ships and 2000 men, being the largest armament, both of ships and men, that had ever been sent from Spain to the new world. Mendoзa died on his return to Spain, but most part of his men remained in the country on the Rio Plata, where they built a large city, containing now 2000 houses, in which great numbers of Indians dwell along with the Spaniards. From this place they discovered and conquered the country to a great extent, even to the mines of Potosi and the town of La Plata167, which is at the distance of 500 miles from Buenos Ayres.

Cortes having learnt, in the year 1536, that his ship, of which Fortunio Ximenez was pilot, had been seized by Nunnez de Guzman, sent three ships to Xalisco, while he marched thither by land with a respectable force; and, on his arrival there, he found his ship all spoiled and rifled. When his small squadron was come round to Xalisco, he went himself on board, and left Andrew de Tapia to command his land force. Setting sail from thence, he came, on the first of May, to a point of land, which he named Cape St Philip, and, to an island close by this cape, he gave the name of St Jago. Three days afterwards, he came to the bay where the pilot Ximenez was killed, which he named Bahia de Santa Cruz, where he went on land, and sent out Andrew de Tapia to explore the country. Cortes again set sail, and came to the river now called Rio de San Pedro y San Paulo, where the ships were separated by a tempest. One was driven to the bay of Santa Cruz, another to the river of Guajaval, and the third was stranded on the coast near Xalisco, whence the crew went overland to Mexico. After waiting a long while for his other two ships, Cortes made sail, and entered into the gulf of California, otherwise called Mar Vermejo, or the Vermilion Sea, and by some, the sea of Cortes. Having penetrated 50 leagues within that gulf, he espied a ship riding at an anchor, and, on his approach towards her, had nearly been lost, if he had not received assistance from that other ship. Having repaired his own ship, he departed from thence with both ships; and, having procured provisions at a very dear rate, at St Michael de Culiacan, he went to the harbour of Santa Cruz, where he received information that Don Antonio de Mendoзa had arrived from Spain as Viceroy of Mexico. He therefore left Francis de Ulloa with the command of his ships, ordering him to proceed on discoveries; and going to Acapulco, he received a messenger from Don Antonio de Mendoзa, the new viceroy, certifying his arrival, and the assumption of his authority. Mendoзa likewise sent him the copy of a letter from Francis Pizarro, stating that Mango, the Inca of Peru, had risen in arms, and assailed the city of Cusco with 100,000 fighting men, having slain his brother, John Pizarro, and above 400 Spaniards, with 200 horses; and that he himself, and the Spanish dominions in Peru, were in imminent danger, unless speedily and effectually assisted.

Cortes, not yet resolved on submitting to the authority of Mendoзa, fitted out two ships, under the command of Ferdinando de Grijalva and one Alvarado, on purpose to discover the route to the Moluccas by the way of the equinoctial line, because the islands of Cloves are under that parallel. They went first to St Michael de Tangarara, in Peru, where they landed succours for Pizarro, and thence, all along the line, to the Moluccas, as they were ordered; and they are said to have sailed above 1000 leagues without sight of land on either side the whole way. At length, in lat. 2° N. they discovered an island named Asea, which was believed to be one of the islands of Cloves. Five hundred leagues farther, more or less, they came to another, which they named Isla de los Pescadores, or island of Fishers. Going still in the same course, they saw another island, called Hayme, on the south side of the line, and another named Apia, after which they came in sight of Seri. Turning one degree to the north, they came to anchor at an island named Coroa, whence they came to another under the line named Memousum, and thence to Busu, still holding on the same course168.