“Oh I will. I always am.”

Outside, Frank sighed. Torrey Pines was looking like a thin reed. But it was his reed, and anything might happen. Derek was good at keeping things afloat. But Sam Houston was a loss. Derek needed Frank there as scientific advisor. Or consultant, given his UCSD position. And if they had Pierzinski under contract, things might work out. By the end of the year the whole Torrey Pines situation might be turned around. And if it all worked out, the potential was there for it to do very well indeed.

Frank wandered down to Leo’s lab. It was noticeably lively compared to the rest of the building people bustling about, the smell of solvents in the air, machines whirring away. Where there’s life there’s hope. Or perhaps they were only like the musicians on the Titanic, playing on while the ship went down.

This, however, represented an attempt to bail the ship out. Frank felt encouraged. He went in and exchanged pleasantries with Leo and his people, feeling that it was easy to be friendly and encouraging. This was the guts of the machine, after all. He mentioned that Derek had sent him down to talk about their current situation, and Leo nodded noncommittally and gave him a rundown, truncated but functional.

Frank regarded him as he spoke, thinking: Here is a scientist at work in a lab. He is in the optimal scientific space. He has a lab, he has a problem, he’s fully absorbed and going full tilt. He should be happy. But he isn’t happy. He has a tough problem he’s trying to solve, but that’s not it; people always have tough problems in the lab.

It was something else. Probably, that he was aware of the company’s situation of course, he had to be. Probably this was the source of his unease. The musicians feeling the tilt in the deck. In which case there really was a kind of heroism in the way they played on, focused to the end.

But for some reason Frank was also faintly annoyed by this. People plugging away in the same old ways, trying to do things according to the plan, even a flawed plan: normal science, in Kuhnian terms, as well as in the more ordinary sense. All so normal, so trusting that the system worked, when obviously the system was both rigged and broken. How could they persevere? How could they be so blinkered, so determined, so dense?

Frank slipped his content in. “Maybe if you had a way to test the genes in computer simulations, find your proteins in advance.”

Leo looked puzzled. “You’d have to have a, what. A theory of how DNA codes its gene expression functions. At the least.”

“Yes.”

“That would be nice, but I’m not aware anyone has that.”

“No, but if you did…Wasn’t George working on something like that, or one of his temporary guys? Pierzinski?”

“Yeah that’s right, Yann was trying some really interesting things. But he left.”

“I think Derek is trying to bring him back.”

“Good idea.”

Then Marta walked into the lab. When she saw Frank she stopped, startled.

“Oh hi Marta.”

“Hi Frank. I didn’t know you were going to be coming by.”

“Neither did I.”

“Oh no? Well ” She hesitated, turned. The situation called for her to say something, he felt, something like Good to see you, if she was going to leave so quickly. But she said only, “I’m late, I’ve got to get to work.”

And then she was out the door.

Only later, when reviewing his actions, did Frank see that he had cut short the talk with Leo and pretty obviously at that in order to follow Marta. In the moment itself he simply found himself walking down the hall, catching up to her before he even realized what he was doing.

She turned and saw him. “What,” she said sharply, looking at him as if to stop him in his tracks.

“Oh hi I was just wondering how you’re doing, I haven’t seen you for a while, I wondered. Are you up for, how about going out and having dinner somewhere and catching up?”

She surveyed him. “I don’t think so. I don’t think that would be a good idea. We might as well not even go there. What would be the point.”

“I don’t know, I’m interested to know how you’re doing I guess is all.”

“Yeah I know, I know what you mean. But sometimes there are things you’re interested in that you can’t really ever get to know anymore, you know?”

“Ah yeah.”

He pursed his lips, looked at her. She looked good. She was both the strongest and the wildest woman he had ever met. Somehow things between them had gone wrong anyway.

Now he looked at her and understood what she was saying. He was never going to be able to know what her life was like these days. He was biased, she was biased; the scanty data would be inescapably flawed. Talking for a couple hours would not make any difference. So it was pointless to try. Would only bring up bad things from the past. Maybe in another ten years. Maybe never.

Marta must have seen something of this train of thought in his face, because with an impatient nod she turned and was gone.

A FEW DAYS after Frank dropped by, Leo turned on his computer when he came in to the lab and saw there was an e-mail from Derek. He opened and read it, then the attachment that had come with it. When he was done he printed it all out, and forwarded it to Brian and Marta. When Marta came in about an hour later she had already done some work on it.

“Hey Brian,” she called from Leo’s door, “come check this out. Derek has sent us a new paper from that Yann Pierzinski who was here. He was funny. It’s a new version of the stuff he was working on when he was here. That was interesting I thought. If we could get it to find us better matching ligands, you might not need the hydrodynamic pressures to get them to stick in the body.”

Brian had come in while she was telling him this, and she pointed to parts of the diagram on Leo’s screen as he caught up. “See what I mean?” Liver cells, endothelial cells all the cells in the body had receptor ligands that were extremely specific for the ligands on the particular proteins that they needed to obtain from the blood; together they formed something like lock-and-key arrangements, coded by the genes and embodied in the proteins. In effect they were locksmithing at the microscopic level, working with living cells as their material.

“Well, yeah. It would be great. If it worked. Maybe crunch them through this program over and over, until you see repeats. If you did…then test the ones with the ligands that fit best and look strongest chemically.”

“And Pierzinski is back to work on it with us!”

“Is he?”

“Yeah, he’s coming back. Derek says in his e-mail that we’ll have him at our disposal.”

“Cool.”

Leo checked this in the company’s directory. “Yep, here he is. Rehired just this week. Frank Vanderwal came by and mentioned this guy, he must have told Derek about it I bet. He was asking me about it too. Well, Vanderwal should know, this is his field.”

“It’s my field too,” Marta said sharply.

“Right, of course, I’m just saying Frank might have, you know. Well, let’s ask Yann to look at what we’ve got. If it works…”

Brian said, “Sure. It’s worth trying anyway. Pretty interesting.” He Googled Yann, and Leo leaned over his shoulder to look at the list.

“Derek obviously wants us to talk to him right away.”

“He must have rehired him for us.”

“I see that. So let’s get him before he gets busy with something else. A lot of labs could use another biomathematician.”

“True, but there aren’t a lot of labs. I think we’ll get him. Look, what do you think Derek means here, ‘write up the possibilities right away.’”

“I suppose he wants to get started using the idea to try to secure more funding.”

“Shit. Yeah, that’s probably right. Unbelievable. Okay, let’s pass on that for now, and give Yann a call.”

Their talk with Yann Pierzinski was indeed interesting. He breezed into the lab just a few days later, as friendly as ever, and happy to be back at Torrey Pines with a permanent job. He was going to be based in George’s math group, he told them, but had already been told by Derek to expect to work a lot with Leo’s lab; so he arrived curious and ready to go.