While the negociation was in this state of forwardness, an unlooked for event rendered all these pacific measures abortive. Ancanamon had a Spanish lady among his wives, who, taking advantage of his absence, fled for refuge to the governor, accompanied by four other women who were wives to the toqui, and two young girls his daughters. The toqui was extremely indignant on this occasion, though less exasperated by the flight of his wives, than by the kind reception they had experienced among the Spaniards. Relinquishing every thought of peace, he immediately returned to the governor, from whom he demanded the restitution of the fugitives. His demand was taken into consideration by a council of the officers; but the majority of these, many of whom were averse to peace, refused to surrender the women to the toqui, alleging that they were unwilling to expose them to the danger of relapsing from the Christian faith which they had embraced. After many ineffectual propositions, Ancanamon consented to limit his demands to the restitution of his daughters, whom he tenderly loved. To this it was answered, that as the eldest had not yet embraced the Christian faith, his request respecting her would be complied with, but as the younger had been already baptised, they could not think of delivering her into his hands.

At this time the almost extinguished hopes of peace were revived for a time by an unexpected incident. Utiflame, the apo-ulmen of Ilicura near Imperial, had always been among the most inveterate enemies of the Spaniards, and to avoid all intercourse with them, had constantly refused to ransom his sons or relations who happened to be made prisoners. He prided himself on having so successfully opposed all the Spanish governors of Chili, from the elder Villagran to Rivera, that the enemy had never been able to acquire a footing in his province, though near the city of Imperial. One of his sons who had been taken in the late war, was about this time sent back to him by Valdivia, in consequence of which he was so highly gratified, that he went immediately to visit the missionary at the fort of Arauco, where in return for the civilities he experienced from the governor and Valdivia, he engaged to receive the missionaries into his province, and to use his influence with Ancanamon to conclude a peace with the Spaniards. He observed, however, that it was necessary in the first place to restore his women, which could be done with safety by obtaining in the first place a safe conduct from the toqui, and undertook to manage the business. He accordingly departed from Arauco for Ilicura, accompanied by three missionaries, one of whom was Horatio Vecchio, the cousin of Pope Alexander VII. The exasperated toqui no sooner learnt the arrival of the missionaries at Ilicura, than he hastened to that place with two hundred horse, and slew them all with their defender Utiflame. Thus were all the plans of pacification rendered abortive, though Valdivia used repeated attempts to revive the negociation. All his schemes were disconcerted by the contrivances of the officers and soldiers, who were interested in the continuance of the war, and loudly demanded that vengeance should be taken for the blood of the slaughtered priests. Notwithstanding his anxious desire for peace and the pious intentions of the king, the governor found himself compelled to prosecute the war, which was renewed with more fury than ever. Ancanamon the toqui, being eager to revenge the affront he had received in regard to his women, incessantly harassed the southern provinces of Spanish Chili, and his successor Loncothegua continued hostilities with equal obstinacy; but only very imperfect accounts of this period of the war have been given by the contemporary historians. The governor Rivera died at Conception in 1617, having appointed as his successor Fernando Talaverano the senior oydor of the royal court; who was succeeded ten months afterwards by Lope de Ulloa.

The toqui Loncothegua resigned in 1618, and was succeeded in the supreme command of the Araucanian armies by an officer named Lientur, whose military expeditions were always so rapid and unexpected, that the Spaniards used to call him the wizard. All his designs were perfectly seconded by Levipillan, his vice toqui. Though the line of the Biobio was amply secured by fortresses and centinels, these indefatigable enemies always contrived to pass and repass without experiencing any material loss. The first enterprise of Lientur was the capture of a convoy of four hundred horses, which were intended to remount the Spanish cavalry. He next ravaged the province of Chilian, and slew the corregidor with two of his sons and several of the magistrates, who had attempted to resist him in the field. Five days afterwards, he proceeded towards St. Philip of Austria, otherwise called Yumbel, a place about sixty miles to the east of Conception, with six hundred infantry and four hundred horse, all of whom he sent out in various detachments to ravage the surrounding country, leaving only two hundred men to guard the narrow defile of Congrejeras. Provoked at this daring enterprise, Robolledo, the commandant of Yumbel, sent seventy horse to take possession of the pass and cut off the retreat of the toqui; but they were received with such bravery by the Araucanian detachment, that they were compelled to retire for security to a neighbouring hill, after losing their captain and eighteen of their number. Robolledo sent three companies of infantry and all the rest of his cavalry to their aid; but Lientur who had by this time collected all his troops together, fell upon the Spaniards, notwithstanding the continual fire of their musquetry, and put their cavalry to flight at the first charge. The infantry, thus left exposed, were almost all cut to pieces, thirty-six of them only being made prisoners, who were distributed among the several provinces of the Arancanian confederacy. If Lientur had then invested Yumbel it must have fallen into his hands; but he deferred the siege till the following year, when his attempt was rendered unsuccessful by the valiant defence of Ximenes who then had the command. On his repulse however, he assaulted and took a fort named Neculgueno, the garrison of which was put to the sword, and all the auxiliaries who dwelt in that neighbourhood were made prisoners. Lientur followed up these successful exploits with others equally fortunate, which are not particularized by contemporary writers, who have given him the title of the darling of fortune.

Ulloa the-governor, more a prey to anxiety and mortification than disease, died on the 20th of November 1620, and was succeeded in the government of Chili by Christoval de la Cerda, a native of Mexico, the eldest oydor, according to the established rule on such occasions. For the more effectual defence of the frontiers on the Biobio, he caused an additional fortress to be constructed, named San Christoval, which still remains. This oydor continued only a year in the government, during which he was continually occupied in defending the Spanish settlements against the enterprises of Lientur, with whom he had many encounters. His successor, Pedro Suarez de Ulloa, continued the war in a similar manner, contenting himself with acting principally on the defensive, till his death on the 11th of December 1624; when he was succeeded by Francisco Alava, his brother-in-law, who retained the office only for six months, being succeeded by Don Luis de Cordova, in March 1625.

Lientar being advanced in years and worn out by continual exertions, resigned his office in 1625, and was succeeded as toqui by Putapichion, a young man whose courage and conduct much resembled his predecessor in office. The new governor of Chili was a commander of extraordinary skill and courage, and being nephew to the viceroy of Peru, was abundantly supplied with troops and warlike stores, being likewise directed by his instructions not to confine himself to defensive operations, but to carry the war into the Araucanian territory. His first care on his arrival at Conception, was to restore the military discipline, and to discharge all arrears that were due to the troops. He at the same time preferred a number of Creoles to the vacant offices, by which he acquired the esteem of all the inhabitants, and gratified many of the descendants of the original conquerors who had been hitherto much neglected. Having established good order in the government, he directed Alonzo de Cordova, whom he had appointed quarter-master, to make an incursion with six hundred men into the provinces of Arauco and Tucapel. In this expedition only an hundred and fifteen prisoners were taken and a small number of cattle, as most of the inhabitants took refuge in the mountains with their families and effects.